Active behavior of triple-negative breast cancer with adipose tissue invasion: a single center and retrospective review.

ABSTRACT:

Background

Interactions between adipocyte and breast cancer (BC) cells have yet to be fully elucidated. Here we investigated the prognostic impact of marginal adipose tissue invasion in both luminal breast cancer (HR+/HER2-) and triple-negative breast cancer (TNBC) (HR-/HER2-).

Methods

A total of 735 patients with early-stage invasive BC (1999-2014) were retrospectively registered. Median length of patient follow-up was 8.9 years. Survival curves were calculated using a Kaplan-Meier cumulative survival plot. The prognostic difference between two groups were assessed by the univariate Cox-proportional hazard regression model.

Results

Patients with adipose tissue invasion (n = 614) had a significantly poorer prognosis than those without adipose tissue invasion (n = 121)

SUBMITTER: Yamaguchi J 

PROVIDER: S-EPMC8056529 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature