A cohort study of membranous nephropathy, primary or secondary.

ABSTRACT:

Background

Although IgG4 deposit against phospholipase A2 receptor (anti-PLA2R) is predominantly presented in the renal biopsy of patients with primary membranous nephropathy (MN), its diagnostic value of this immune complex has not been fully established.

Methods

In this cohort study, 108 biopsy-proven MN patients with proteinuria were evaluated during two years follow up and were divided into primary and secondary groups. Renal biopsy specimens were pathologically assessed for IgG4 and PLA2R depositions by immunohistochemistry (IHC). Therefore, the relationships between staining severity, MN type and total proteinuria in all patients were determined.

Results

Of 108 patients, 73.1% had primary MN and 26.9% were diagnosed as secondary form. IHC staining in patients wi

SUBMITTER: Arghiani M 

PROVIDER: S-EPMC8056567 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature