High levels of anti-Leishmania IgG3 and low CD4⁺ T cells count were associated with relapses in visceral leishmaniasis.

ABSTRACT:

Background

Visceral leishmaniasis (VL) is severe and potentially fatal. Brazil is one of the countries with the greatest endemicity for the disease in the world. The reduction of CD4⁺ T lymphocytes, B cells activation and high levels of inflammatory cytokines (IL-6/IL-8/TNF/IL-1β), plasma LPS, soluble CD14, anti-Leishmania IgG3 and low leptin levels are involved in the immunopathogenesis of VL, most associated with severe VL. Despite relapses occurring in about 4-5% of patients with VL not associated with HIV infection, the factors underlying relapses are little known. Our aim was to identify clinical, laboratory and immunological parameters that may be associated with recurrences in VL.

Methods

Fifteen VL patients recruited from Hospital Eduardo de Menezes (BH-MG

SUBMITTER: Kuschnir RC 

PROVIDER: S-EPMC8056614 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature