Guidelines are needed for studies of pre-treatment HIV drug resistance: a methodological study.

ABSTRACT:

Background

The expansion of access to antiretroviral therapy (ART) has been accompanied by an increase in pre-treatment drug resistance (PDR). While it is critical to monitor the increasing prevalence of PDR across countries and populations to inform optimal regimen selection, the completeness of reporting is often suboptimal, limiting the interpretation and generalizability of the results. Indeed, there is no formal guidance on how studies investigating the prevalence of drug resistance should be reported. Thus, we sought to determine the completeness of reporting in studies of PDR and the factors associated with sub-optimal reporting to ascertain the need for guidelines.

Methods

As part of a systematic review on the global prevalence of PDR in key populations (men who have

SUBMITTER: Mbuagbaw L 

PROVIDER: S-EPMC8056637 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature