Gene network analyses unveil possible molecular basis underlying drug-induced glaucoma.

ABSTRACT:

Background

Drug-induced glaucoma (DIG) is a kind of serious adverse drug reaction that can cause irreversible blindness. Up-to-date, the molecular mechanism of DIG largely remains unclear yet due to the medical complexity of glaucoma onset.

Methods

In this study, we conducted data mining of tremendous historical adverse drug events and genome-wide drug-regulated gene signatures to identify glaucoma-associated drugs. Upon these drugs, we carried out serial network analyses, including the weighted gene co-expression network analysis (WGCNA), to illustrate the gene interaction network underlying DIG. Furthermore, we applied pathogenic risk assessment to discover potential biomarker genes for DIG.

Results

As the results, we discovered 13 highly glaucoma-associated drugs,

SUBMITTER: Ding RF 

PROVIDER: S-EPMC8056654 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature