Capturing cognitive and behavioral variability among individuals with Down syndrome: a latent profile analysis.

ABSTRACT:

Background

There is a high degree of inter- and intra-individual variability observed within the phenotype of Down syndrome. The Down Syndrome Cognition Project was formed to capture this variability by developing a large nationwide database of cognitive, behavioral, health, and genetic information on individuals with Down syndrome, ages 6-25 years. The current study used the Down Syndrome Cognition Project database to characterize cognitive and behavioral variability among individuals with Down syndrome.

Methods

Latent profile analysis was used to identify classes across a sample of 314 participants based on their cognition (IQ and executive functioning), adaptive and maladaptive behavior, and autism spectrum disorder symptomatology. A multivariate multinomial regression mo

SUBMITTER: Channell MM 

PROVIDER: S-EPMC8056665 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature