Optimal dosing for psilocybin pharmacotherapy: Considering weight-adjusted and fixed dosing approaches.

ABSTRACT:

Background

Growing evidence suggests psilocybin, a naturally occurring psychedelic, is a safe and promising pharmacotherapy for treatment of mood and substance use disorders when administered as part of a structured intervention. In most trials to date, psilocybin dose has been administered on a weight-adjusted basis rather than the more convenient procedure of administering a fixed dose.

Aims

The present post hoc analyses sought to determine whether the subjective effects of psilocybin are affected by body weight when psilocybin is administered on a weight-adjusted basis and when psilocybin is administered as a fixed dose.

Methods

We analyzed acute subjective drug effects (mystical, challenging, and intensity) associated with therapeutic outcomes from ten previous st

SUBMITTER: Garcia-Romeu A 

PROVIDER: S-EPMC8056712 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature