Warfarin dosing algorithms: A systematic review.

ABSTRACT:

Aims

Numerous algorithms have been developed to guide warfarin dosing and improve clinical outcomes. We reviewed the algorithms available for various populations and the covariates, performances and risk of bias of these algorithms.

Methods

We systematically searched MEDLINE up to 20 May 2020 and selected studies describing the development, external validation or clinical utility of a multivariable warfarin dosing algorithm. Two investigators conducted data extraction and quality assessment.

Results

Of 10 035 screened records, 266 articles were included in the review, describing the development of 433 dosing algorithms, 481 external validations and 52 clinical utility assessments. Most developed algorithms were for dose initiation (86%), developed by multiple linear r

SUBMITTER: Asiimwe IG 

PROVIDER: S-EPMC8056736 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature