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Elasticizing tissues for reversible shape transformation and accelerated molecular labeling.

ABSTRACT: We developed entangled link-augmented stretchable tissue-hydrogel (ELAST), a technology that transforms tissues into elastic hydrogels to enhance macromolecular accessibility and mechanical stability simultaneously. ELASTicized tissues are highly stretchable and compressible, which enables reversible shape transformation and faster delivery of probes into intact tissue specimens via mechanical thinning. This universal platform may facilitate rapid and scalable molecular phenotyping of large-scale biological systems, such as human organs.

SUBMITTER: Ku T

PROVIDER: S-EPMC8056749 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Elasticizing tissues for reversible shape transformation and accelerated molecular labeling.

Ku Taeyun T Guan Webster W Evans Nicholas B NB Sohn Chang Ho CH Albanese Alexandre A Kim Joon-Goon JG Frosch Matthew P MP Chung Kwanghun K

Nature methods 20200518 6

We developed entangled link-augmented stretchable tissue-hydrogel (ELAST), a technology that transforms tissues into elastic hydrogels to enhance macromolecular accessibility and mechanical stability simultaneously. ELASTicized tissues are highly stretchable and compressible, which enables reversible shape transformation and faster delivery of probes into intact tissue specimens via mechanical thinning. This universal platform may facilitate rapid and scalable molecular phenotyping of large-scal ...[more]

PMID: 32424271

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