Efficacy and safety of lopinavir-ritonavir in COVID-19: A systematic review of randomized controlled trials.

ABSTRACT:

Background

Lopinavir-ritonavir is a repurposed drug for coronavirus disease-2019 (COVID-19). In this study, a pooled effect of lopinavir-ritonavir on mortality, virological cure, radiological improvement and safety profile in COVID-19 patients has been evaluated.

Methods

The databases were searched for comparative randomized controlled studies evaluating the efficacy and/or safety of lopinavir-ritonavir in COVID-19 patients. The mortality outcome was pooled as a risk difference (RD) with 95% CI. The virological cure, radiological improvement and adverse events were pooled as risk ratio (RR) with 95% CI. All outcomes were pooled using the Mantle-Hanzle method random effect model. The heterogeneity was assessed using the I² test.

Results

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SUBMITTER: Patel TK 

PROVIDER: S-EPMC8056786 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature