Fetal programming of polycystic ovary syndrome: Effects of androgen exposure on prenatal ovarian development.

ABSTRACT: Polycystic ovary syndrome (PCOS) is a common form of anovulatory infertility with a strong hereditary component but no candidate genes have been found. The inheritance pattern may be due to in utero androgen programming on gene expression and mitochondria. Mitochondria are maternally inherited and alterations to mitochondria after fetal androgen exposure may explain one of the mechanisms of fetal programming in PCOS. Our aim was to investigate the role of excessive prenatal androgens in ovarian development by identifying how hyperandrogenemia affects gene expression and mitochondria in neonatal ovary. Pregnant dams were injected with dihydrotestosterone on days 16-18 of pregnancy. Day 0 ovaries were collected for gene expression and mitochondrial studies. RNAseq showed differential gene ex

SUBMITTER: Barsky M 

PROVIDER: S-EPMC8056856 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature