Telomere Length and Psychopathology: Specificity and Direction of Effects Within the Bucharest Early Intervention Project.

ABSTRACT:

Objective

Telomere length (TL) has been linked to several psychiatric conditions in children and adults. Telomere shortening is accelerated by early adversity, including maltreatment and psychosocial deprivation. These experiences also increase the risk of psychopathology in many domains. Two fundamental issues remain unresolved. The first concerns the specificity of the relations between TL and different dimensions of psychopathology; and the second relates to the direction of association between TL and psychopathology.

Method

This study addressed these shortcomings in a 2-fold manner. First, the association between TL and statistically independent general, internalizing, and externalizing psychopathology factors was examined to determine the specificity of this relation. S

SUBMITTER: Wade M 

PROVIDER: S-EPMC8056885 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature