Guillain-Barre Syndrome Outbreak in Peru 2019 Associated With Campylobacter jejuni Infection.

ABSTRACT:

Objective

To identify the clinical phenotypes and infectious triggers in the 2019 Peruvian Guillain-Barré syndrome (GBS) outbreak.

Methods

We prospectively collected clinical and neurophysiologic data of patients with GBS admitted to a tertiary hospital in Lima, Peru, between May and August 2019. Molecular, immunologic, and microbiological methods were used to identify causative infectious agents. Sera from 41 controls were compared with cases for antibodies to Campylobacter jejuni and gangliosides. Genomic analysis was performed on 4 C jejuni isolates.

Results

The 49 included patients had a median age of 44 years (interquartile range [IQR] 30-54 years), and 28 (57%) were male. Thirty-two (65%) had symptoms of a preceding infection: 24 (49%) diarrhea and

SUBMITTER: Ramos AP 

PROVIDER: S-EPMC8057064 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature