Identification and characterization of B220⁺/B220^- subpopulations in murine Gr1⁺CD11b⁺ cells during tumorigenesis.

ABSTRACT: Although all murine MDSCs are defined as Gr1⁺CD11b⁺, their true immunophenotype remains elusive. In this study, we found murine Gr1⁺CD11b⁺ cells can be divided into two subsets: Gr1⁺CD11b⁺B220^- and Gr1⁺CD11b⁺B220⁺, especially in the spleen tissues. Unlike the dominant B220^- subset, the B220⁺ subpopulation was not induced by tumor in vivo. Moreover, Gr1⁺CD11b⁺B220⁺ cells from tumor-bearing mice spleens were unable to induce arginase 1 and inducible nitric oxide synthase expression, inhibit T cell proliferation, or promote tumor growth in primary tumor site. Nevertheless, these cells suppressed tumor metastasis in vivo<

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC8057082 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature