Urinary Sodium and Potassium, and Risk of Ischemic and Hemorrhagic Stroke (INTERSTROKE): A Case-Control Study.

ABSTRACT:

Background

Although low sodium intake (<2 g/day) and high potassium intake (>3.5 g/day) are proposed as public health interventions to reduce stroke risk, there is uncertainty about the benefit and feasibility of this combined recommendation on prevention of stroke.

Methods

We obtained random urine samples from 9,275 cases of acute first stroke and 9,726 matched controls from 27 countries and estimated the 24-hour sodium and potassium excretion, a surrogate for intake, using the Tanaka formula. Using multivariable conditional logistic regression, we determined the associations of estimated 24-hour urinary sodium and potassium excretion with stroke and its subtypes.

Results

Compared with an estimated urinary sodium excretion of 2.8-3.5 g/day (reference), higher (>4.26

SUBMITTER: Judge C 

PROVIDER: S-EPMC8057138 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature