Impact of neoadjuvant androgen deprivation therapy on magnetic resonance imaging features in prostate cancer before radiotherapy.

ABSTRACT:

Background and purpose

In locally advanced prostate cancer (PC), androgen deprivation therapy (ADT) in combination with whole prostate radiotherapy (RT) is the standard treatment. ADT affects the prostate as well as the tumour on multiparametric magnetic resonance imaging (MRI) with decreased PC conspicuity and impaired localisation of the prostate lesion. Image texture analysis has been suggested to be of aid in separating tumour from normal tissue. The aim of the study was to investigate the impact of ADT on baseline defined MRI features in prostate cancer with the goal to investigate if it might be of use in radiotherapy planning.

Materials and methods

Fifty PC patients were included. Multiparametric MRI was performed before, and three months after ADT. At baseline, a tum

SUBMITTER: Bjoreland U 

PROVIDER: S-EPMC8058024 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature