Dataset Information

Evolution of the hypoxic compartment on sequential oxygen partial pressure maps during radiochemotherapy in advanced head and neck cancer.

ABSTRACT:

Background and purpose

Longitudinal Positron Emission Tomography (PET) with hypoxia-specific radiotracers allows monitoring the time evolution of regions of increased radioresistance and may become fundamental in determining the radiochemotherapy outcome in Head-and-Neck Squamous Cell Carcinoma (HNSCC). The aim of this study was to investigate the evolution of the hypoxic target volume on oxygen partial pressure maps (pO₂-HTV) derived from ¹⁸FMISO-PET images acquired before and during radiochemotherapy and to uncover correlations between extent and severity of hypoxia and treatment outcome.

Material and methods

¹⁸FMISO-PET/CT images were acquired at three time points (before treatment start, in weeks two and five) for twenty-eight HNSCC patients treated with radiochemotherapy. The images were converted into pO₂ maps and corresponding pO₂-HTVs (pO₂-HTV₁, pO₂-HTV₂, pO₂-HTV₃) were contoured at 10 mmHg. Different parameters describing the pO₂-HTV time evolution were considered, such as the percent and absolute difference between the pO₂-HTVs (%HTV_i,j and HTV_i-HTV_j with i,j = 1, 2, 3, respectively) and the slope of the linear regression curve fitting the pO₂-HTVs in time. Correlations were sought between the pO₂-HTV evolution parameters and loco-regional recurrence (LRR) using the Receiver Operating Characteristic method.

Results

The Area Under the Curve values for %HTV_1,2, HTV₁-HTV₂, HTV₁-HTV₃ and the slope of the pO₂-HTV linear regression curve were 0.75 (p = 0.04), 0.73 (p = 0.02), 0.73 (p = 0.02) and 0.75 (p = 0.007), respectively. Other parameter combinations were not statistically significant.

Conclusions

The pO₂-HTV evolution during radiochemotherapy showed predictive value for LRR. The changes in the tumour hypoxia during the first two treatment weeks may be used for adaptive personalized treatment approaches.

SUBMITTER: Lazzeroni M

PROVIDER: S-EPMC8058025 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Publications

Evolution of the hypoxic compartment on sequential oxygen partial pressure maps during radiochemotherapy in advanced head and neck cancer.

Lazzeroni Marta M Ureba Ana A Wiedenmann Nicole N Nicolay Nils H NH Mix Michael M Thomann Benedikt B Baltas Dimos D Toma-Dasu Iuliana I Grosu Anca L AL

Physics and imaging in radiation oncology 20210101

<h4>Background and purpose</h4>Longitudinal Positron Emission Tomography (PET) with hypoxia-specific radiotracers allows monitoring the time evolution of regions of increased radioresistance and may become fundamental in determining the radiochemotherapy outcome in Head-and-Neck Squamous Cell Carcinoma (HNSCC). The aim of this study was to investigate the evolution of the hypoxic target volume on oxygen partial pressure maps (pO<sub>2</sub>-HTV) derived from <sup>18</sup>FMISO-PET images acquire ...[more]

PMID: 33898787

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Dataset Information

Evolution of the hypoxic compartment on sequential oxygen partial pressure maps during radiochemotherapy in advanced head and neck cancer.

Background and purpose

Material and methods

Results

Conclusions

Publications

Evolution of the hypoxic compartment on sequential oxygen partial pressure maps during radiochemotherapy in advanced head and neck cancer.

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