Plasma LDH: A specific biomarker for lung affectation in COVID-19?

ABSTRACT:

Objectives

We aimed to determine whether the plasma profile of lactate dehydrogenase (LDH) isoenzymes is altered in patients with COVID-19, and whether this is attributable to a specific release of LDH-3, the main LDH isoenzyme expressed in lungs.

Design

We collected fresh plasma aliquots from 17 patients (LDH range, 281-822 U/L) and seven controls (LDH ​< ​230 U/L). In-gel relative activity of the different LDH isoenzymes was determined by electrophoresis and densitometric analysis.

Results

Despite the expected higher total LDH activity levels in patients (p ​< ​0.001), the in-gel relative activities of LDH isoenzymes did not differ between patients and controls (all p ​> ​0.05). We found no correlation between total plasma LDH activity and the in-gel relative activi

SUBMITTER: Serrano-Lorenzo P 

PROVIDER: S-EPMC8058053 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature