Deficits in hippocampal-dependent memory across different rodent models of early life stress: systematic review and meta-analysis.

ABSTRACT: Exposure to early life stress (ELS) causes abnormal hippocampal development and functional deficits in rodents and humans, but no meta-analysis has been used yet to quantify the effects of different rodent models of ELS on hippocampal-dependent memory. We searched PubMed and Web of Science for publications that assessed the effects of handling, maternal separation (MS), and limited bedding and nesting (LBN) on performance in the Morris water maze (MWM), novel object recognition (NOR), and contextual fear conditioning (CFC). Forty-five studies met inclusion criteria (n = 451-763 rodents per test) and were used to calculate standardized mean differences (Hedge's g) and to assess heterogeneity, publication bias, and the moderating effects of sex and species (rats vs. mice). We found significa

SUBMITTER: Rocha M 

PROVIDER: S-EPMC8058062 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature