Mitochondrial quality control protects photoreceptors against oxidative stress in the H₂O₂-induced models of retinal degeneration diseases.

ABSTRACT: Retinal degeneration diseases (RDDs) are common and devastating eye diseases characterized by the degeneration of photoreceptors, which are highly associated with oxidative stress. Previous studies reported that mitochondrial dysfunction is associated with various neurodegenerative diseases. However, the role of mitochondrial proteostasis mainly regulated by mitophagy and mitochondrial unfolded protein response (mtUPR) in RDDs is unclear. We hypothesized that the mitochondrial proteostasis is neuroprotective against oxidative injury in RDDs. In this study, the data from our hydrogen peroxide (H₂O₂)-treated mouse retinal cone cell line (661w) model of RDDs showed that nicotinamide riboside (NR)-activated mitophagy increased the expression of LC3B II and PINK1, and prom

SUBMITTER: Zhou B 

PROVIDER: S-EPMC8058096 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature