Mechanically tuned vascular graft demonstrates rapid endothelialization and integration into the porcine iliac artery wall.

ABSTRACT: Mechanical properties of vascular grafts likely play important roles in healing and tissue regeneration. Healthy arteries are compliant at low pressures but stiffen rapidly with increasing load, ensuring sufficient volumetric expansion without overstretching the vessel. Commercial synthetic vascular grafts are stiff and unable to expand under physiologic loads, which may result in altered hemodynamics, deleterious cellular responses, and compromised clinical performance. The goal of this study was to develop an Elastomeric Nanofibrillar Graft (ENG) with artery-tuned nonlinear compliance and compare its healing responses to conventional expanded polytetrafluoroethylene (ePTFE) grafts in a porcine iliac artery model. Human and porcine iliac arteries were mechanically characterized, and an EN

SUBMITTER: Maleckis K 

PROVIDER: S-EPMC8058268 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature