Unknown

Dataset Information

0

Disposition of PCB 11 in Mice Following Acute Oral Exposure.

ABSTRACT: PCB 11 (3,3'-dichloro-biphenyl) is an emerging environmental contaminant that represents a public health concern. Here, we investigated the distribution of PCB 11 and its metabolites in mice exposed orally to PCB 11. PCB 11 tissue levels followed the rank order adipose > lung ∼ muscle > liver > brain > blood 4 h after PCB 11 exposure, which varied from the rank order predicted with a composition-based model. We detected hydroxylated and sulfate metabolites in the liver and sulfate and glucuronide metabolites in serum. These findings lay the groundwork for future toxicity studies with PCB 11.

SUBMITTER: Zhang CY 

PROVIDER: S-EPMC8058299 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Disposition of PCB 11 in Mice Following Acute Oral Exposure.

Zhang Chun-Yun CY   Klocke Carolyn R CR   Lein Pamela J PJ   Lehmler Hans-Joachim HJ  

Chemical research in toxicology 20210318 4

PCB 11 (3,3'-dichloro-biphenyl) is an emerging environmental contaminant that represents a public health concern. Here, we investigated the distribution of PCB 11 and its metabolites in mice exposed orally to PCB 11. PCB 11 tissue levels followed the rank order adipose > lung ∼ muscle > liver > brain > blood 4 h after PCB 11 exposure, which varied from the rank order predicted with a composition-based model. We detected hydroxylated and sulfate metabolites in the liver and sulfate and glucuronid  ...[more]

Similar Datasets

Unknown Comparative disposition of dimethylaminoethanol and choline in rats and mice following oral or intravenous administration.
| S-EPMC7252906 | biostudies-literature
Unknown Hepatic metabolism affects the atropselective disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in mice.
| S-EPMC4291784 | biostudies-literature
Unknown The Bladder as a Target for PCB Toxicity: Evidence from PCB Levels, Phase I Metabolite Levels, and Cytochrome P450 Expression Following Developmental Exposure to a Human-Relevant PCB Mixture in Mice.
| S-EPMC12914705 | biostudies-literature
Unknown Cylindrospermopsin toxicity in mice following a 90-d oral exposure.
| S-EPMC6764423 | biostudies-literature
Transcriptomics Acute hepatic transcriptional response in male mice following oral exposure to benzo(a)pyrene
2015-07-01 | GSE43633 | GEO
Transcriptomics Acute hepatic transcriptional response in male mice following oral exposure to benzo(a)pyrene
2015-07-01 | E-GEOD-43633 | biostudies-arrayexpress
Unknown Acute liver effects, disposition and metabolic fate of [<sup>14</sup>C]-fenclozic acid following oral administration to normal and bile-cannulated male C57BL/6J mice.
| S-EPMC5489613 | biostudies-literature
Unknown Editor's Highlight: Congener-Specific Disposition of Chiral Polychlorinated Biphenyls in Lactating Mice and Their Offspring: Implications for PCB Developmental Neurotoxicity.
| S-EPMC6070089 | biostudies-literature
Unknown Nrf2a dependent and independent effects of early life exposure to 3,3'-dichlorobiphenyl (PCB-11) in zebrafish (Danio rerio).
| S-EPMC9701526 | biostudies-literature
Unknown Effect of pregnancy on the disposition of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) atropisomers and their hydroxylated metabolites in female mice.
| S-EPMC4579038 | biostudies-literature