Evidence of upregulation of the cholinergic anti-inflammatory pathway in late-life depression.

ABSTRACT:

Background

Decreased cholinergic tone associated with increased proinflammatory cytokines has been observed in several human diseases associated with low-grade inflammation. We examined if this attenuated cholinergic anti-inflammatory pathway (CAP) mechanism contributed to increased neuroinflammation observed in depression.

Methods

We measured cerebrospinal fluid (CSF) cholinergic markers (AChE and BChE activities) in 28 individuals with longstanding late-life major depression (LLMD) and 19 controls and their relationship to central and peripheral levels of pro-inflammatory cytokines (IL-6 and IL-8). Additionally, we examined if these cholinergic indices were related to CSF markers of microglial activation and neuroinflammation (sTREM2 and complement C3).

Results

Comp

SUBMITTER: Pomara N 

PROVIDER: S-EPMC8058311 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature