Telomere Maintenance Pathway Activity Analysis Enables Tissue- and Gene-Level Inferences.

ABSTRACT: Telomere maintenance is one of the mechanisms ensuring indefinite divisions of cancer and stem cells. Good understanding of telomere maintenance mechanisms (TMM) is important for studying cancers and designing therapies. However, molecular factors triggering selective activation of either the telomerase dependent (TEL) or the alternative lengthening of telomeres (ALT) pathway are poorly understood. In addition, more accurate and easy-to-use methodologies are required for TMM phenotyping. In this study, we have performed literature based reconstruction of signaling pathways for the ALT and TEL TMMs. Gene expression data were used for computational assessment of TMM pathway activities and compared with experimental assays for TEL and ALT. Explicit consideration of pathway topology makes bioi

SUBMITTER: Nersisyan L 

PROVIDER: S-EPMC8058386 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature