Vitamin D Resistance as a Possible Cause of Autoimmune Diseases: A Hypothesis Confirmed by a Therapeutic High-Dose Vitamin D Protocol.

ABSTRACT: Vitamin D₃ (cholecalciferol) is a secosteroid and prohormone which is metabolized in various tissues to the biologically most active vitamin D hormone 1,25(OH)₂D₃ (calcitriol). 1,25(OH)₂D₃ has multiple pleiotropic effects, particularly within the immune system, and is increasingly utilized not only within prophylaxis, but also within therapy of various diseases. In this context, the latest research has revealed clinical benefits of high dose vitamin D₃ therapy in autoimmune diseases. The necessity of high doses of vitamin D₃ for treatment success can be explained by the concept of an acquired form of vitamin D resistance. Its etiology is based on the one hand on polymorphisms within genes affecting the vitamin D s

SUBMITTER: Lemke D 

PROVIDER: S-EPMC8058406 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature