Determinants of Serum Immunoglobulin Levels: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

An up-to-date overview of determinants of serum immunoglobulins in adults is pivotal for clinical practice and research, but currently lacking. We therefore performed a systematic review and meta-analysis to identify determinants of serum immunoglobulin levels.

Methods

Embase, Web of Science, Medline, Cochrane, and Google Scholar were searched from inception to July 11^th, 2019 for articles reporting on determinants of serum immunoglobulin A, G or M (IgA, IgG or IgM) in adult humans. Random and fixed effect models were applied to obtain pooled mean differences (MDs) and 95% confidence intervals (CIs) for the association of age and sex with serum immunoglobulins.

Results

We retrieved 117 articles reporting on determinants of serum immunoglobulins,

SUBMITTER: Khan SR 

PROVIDER: S-EPMC8058410 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature