Visualization and Identification of Bioorthogonally Labeled Exosome Proteins Following Systemic Administration in Mice.

ABSTRACT: Exosomes transport biologically active cargo (e.g., proteins and microRNA) between cells, including many of the paracrine factors that mediate the beneficial effects associated with stem-cell therapy. Stem cell derived exosomes, in particular mesenchymal stem cells (MSCs), have been shown previously to largely replicate the therapeutic activity associated with the cells themselves, which suggests that exosomes may be a useful cell-free alternative for the treatment of cardiovascular disorders. However, the mechanisms that govern how exosomes home to damaged cells and tissues or the uptake and distribution of exosomal cargo are poorly characterized, because techniques for distinguishing between exosomal proteins and proteins in the targeted tissues are lacking. Here, we report the developme

SUBMITTER: Zhang E 

PROVIDER: S-EPMC8058422 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature