Microglial vesicles improve post-stroke recovery by preventing immune cell senescence and favoring oligodendrogenesis.

ABSTRACT: Contrasting myelin damage through the generation of new myelinating oligodendrocytes represents a promising approach to promote functional recovery after stroke. Here, we asked whether activation of microglia and monocyte-derived macrophages affects the regenerative process sustained by G protein-coupled receptor 17 (GPR17)-expressing oligodendrocyte precursor cells (OPCs), a subpopulation of OPCs specifically reacting to ischemic injury. GPR17-iCreER^T2:CAG-eGFP reporter mice were employed to trace the fate of GPR17-expressing OPCs, labeled by the green fluorescent protein (GFP), after permanent middle cerebral artery occlusion. By microglia/macrophages pharmacological depletion studies, we show that innate immune cells favor GFP⁺ OPC reaction and limit myelin damage

SUBMITTER: Raffaele S 

PROVIDER: S-EPMC8058432 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature