Intestinal function is impaired in patients with Chronic Obstructive Pulmonary Disease.

ABSTRACT:

Background & aims

Gastrointestinal symptoms are prevalent extrapulmonary systemic manifestations of Chronic Obstructive Pulmonary Disease (COPD), but have been rarely studied. We dissected the perturbations in intestinal function in human patients with COPD using comprehensive metabolic and physiological approaches.

Methods

In this observational study, small intestinal membrane integrity and active carrier-mediated glucose transport were quantified by sugar permeability test in 21 clinically stable patients with moderate to severe COPD (mean FEV₁, 41.2 (3.2) % of predicted) and 16 healthy control subjects. Protein digestion and absorption was analyzed using stable tracer kinetic methods. Plasma acetate, propionate, and butyrate concentrations were measured as mark

SUBMITTER: Kirschner SK 

PROVIDER: S-EPMC8058450 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature