Profiling Oncogenic Germline Mutations in Unselected Chinese Lung Cancer Patients.

ABSTRACT:

Introduction

Emerging evidence has suggested that inherited factors are also involved in lung cancer development. However, most studies focused on well-elucidated cancer predisposition genes, the majority of which are tumor suppressor genes. The profile of germline mutations in oncogenic driver genes remains unrevealed, which might also provide potential clinical implications for lung cancer management.

Methods

Sequencing data from 36,813 unselected lung cancer patients who underwent somatic mutation profiling were retrospectively reviewed. All recruited patients had matched white blood cell samples sequenced in parallel using a capture-based panel including eight key lung cancer driver genes (epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK

SUBMITTER: Yang J 

PROVIDER: S-EPMC8058453 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature