The Transcription Regulator Patz1 Is Essential for Neural Stem Cell Maintenance and Proliferation.

ABSTRACT: Proper regulation of neurogenesis, the process by which new neurons are generated from neural stem and progenitor cells (NS/PCs), is essential for embryonic brain development and adult brain function. The transcription regulator Patz1 is ubiquitously expressed in early mouse embryos and has a key role in embryonic stem cell maintenance. At later stages, the detection of Patz1 expression mainly in the developing brain suggests a specific involvement of Patz1 in neurogenesis. To address this point, we first got insights in Patz1 expression profile in different brain territories at both embryonic and postnatal stages, evidencing a general decreasing trend with respect to time. Then, we performed in vivo and ex vivo analysis of Patz1-knockout mi

SUBMITTER: Mancinelli S 

PROVIDER: S-EPMC8058466 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature