Regulation of Cunninghamella spp. biofilm growth by tryptophol and tyrosol.

ABSTRACT: Fungi belonging to the genus Cunninghamella are often used as microbial models of mammalian metabolism owing to their ability to transform a range of xenobiotic compounds. Furthermore, under specific growth conditions species such as Cunninghamella elegans and Cunninghamella echinulata grow as biofilms enabling a convenient semi-continuous production of valuable drug metabolites. However, the molecular mechanism of biofilm regulation is not understood, thus controlling biofilm thickness limits the productive applications of it. In this paper we describe the identification of two molecules, tyrosol and tryptophol, that were identified in C. blakesleeana cultures, but not in C. elegans and C. echinulata. The molecules are known quorum s

SUBMITTER: Khan MF 

PROVIDER: S-EPMC8058532 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature