Comparative analysis of triple-negative breast cancer transcriptomics of Kenyan, African American and Caucasian Women.

ABSTRACT:

Purpose

Triple-negative breast cancer (TNBC) patients of various ethnic groups often have discrete clinical presentations and outcomes. Women of African descent have a disproportionately higher chance of developing TNBCs. The aim of the current study was to establish the transcriptome of TNBCs from Kenyan (KE) women of Bantu origin and compare it to those TNBCs of African-Americans (AA) and Caucasians (CA) for identifying KE TNBC-specific molecular determinants of cancer progression and potential biomarkers of clinical outcomes.

Patients and methods

Pathology-confirmed TNBC tissues from Kenyan women of Bantu origin (n = 15) and age and stage range matched AA (n = 19) and CA (n = 23) TNBCs of patients from Alabama were included in this study. RNA was isolated from paraffin-em

SUBMITTER: Saleh M 

PROVIDER: S-EPMC8058567 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature