External Evaluation of Vancomycin Population Pharmacokinetic Models at Two Clinical Centers.

ABSTRACT: Background: Numerous vancomycin population pharmacokinetic models in neonates have been published; however, their predictive performances remain unknown. This study aims to evaluate their external predictability and explore the factors that might affect model performance. Methods: Published population pharmacokinetic models in neonates were identified from the literature and evaluated using datasets from two clinical centers, including 171 neonates with a total of 319 measurements of vancomycin levels. Predictive performance was assessed by prediction- and simulation-based diagnostics and Bayesian forecasting. Furthermore, the effect of model structure and a number of identified covariates was also investigated. Results: Eighteen published pharmacokinetic models of van

SUBMITTER: Liu YX 

PROVIDER: S-EPMC8058705 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature