Saikosaponin D exhibits anti-leukemic activity by targeting FTO/m⁶A signaling.

ABSTRACT: Purpose: The implementation of targeted therapies for acute myeloid leukemia (AML) has been challenging. Fat mass and obesity associated protein (FTO), an mRNA N⁶-methyladenosine (m⁶A) demethylase, functions as an oncogene that promotes leukemic oncogene-mediated cell transformation and leukemogenesis. Here, we investigated the role of Saikosaponin-d (SsD) in broad anti-proliferation effects in AML and evaluated the m⁶A demethylation activity by targeting FTO of SsD. Methods: It was examined whether and how SsD regulates FTO/m⁶A signaling in AML. The pharmacologic activities and mechanisms of actions of SsD in vitro, in mice, primary patient cells, and tyrosine kinase inhibitors-resistant cells were determined. Results:

SUBMITTER: Sun K 

PROVIDER: S-EPMC8058711 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature