ResiRole: residue-level functional site predictions to gauge the accuracies of protein structure prediction techniques.

ABSTRACT:

Motivation

Methods to assess the quality of protein structure models are needed for user applications. To aid with the selection of structure models and further inform the development of structure prediction techniques, we describe the ResiRole method for the assessment of the quality of structure models.

Results

Structure prediction techniques are ranked according to the results of round-robin, head-to-head comparisons using difference scores. Each difference score was defined as the absolute value of the cumulative probability for a functional site prediction made with the FEATURE program for the reference structure minus that for the structure model. Overall, the difference scores correlate well with other model quality metrics; and based on benchmarking studies with Naïv

SUBMITTER: Toth JM 

PROVIDER: S-EPMC8058773 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature