Clozapine prescribing: comparison of clozapine dosage and plasma levels between White British and Bangladeshi patients.

ABSTRACT:

Aims and method

To compare differences in clozapine doses and plasma levels between Bangladeshi and White British patients. Following ethical approval we identified all current Bangladeshi and White British patients on clozapine maintenance in an east London clinic. We carried out univariate and multivariate regression analyses to examine associations between clozapine doses and ethnicity, age, gender, smoking status and weight. We also compared plasma clozapine levels of the two groups.

Results

On univariate analysis White British patients had on average 85 mg higher doses than Bangladeshi patients (P = 0.004). Older age, male gender and smoking were also associated with higher dose. On multivariate analysis only age and smoking status remained significant. A greater propor

SUBMITTER: Bhattacharya R 

PROVIDER: S-EPMC8058897 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature