Multiple measures of depression to enhance validity of major depressive disorder in the UK Biobank.

ABSTRACT:

Background

The UK Biobank contains data with varying degrees of reliability and completeness for assessing depression. A third of participants completed a Mental Health Questionnaire (MHQ) containing the gold-standard Composite International Diagnostic Interview (CIDI) criteria for assessing mental health disorders.

Aims

To investigate whether multiple observations of depression from sources other than the MHQ can enhance the validity of major depressive disorder (MDD).

Method

In participants who did not complete the MHQ, we calculated the number of other depression measures endorsed, for example from hospital episode statistics and interview data. We compared cases defined this way with CIDI-defined cases for several estimates: the variance explained by polygenic ris

SUBMITTER: Glanville KP 

PROVIDER: S-EPMC8058908 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature