Dataset Information

Irritability through Research Domain Criteria: an opportunity for transdiagnostic conceptualisation.

ABSTRACT: Irritability is a transdiagnostic phenomenon that, despite its ubiquity and significant impact, is poorly conceptualised, defined and measured. As it lacks specificity, efforts to examine irritability in adults by using a diagnostic category perspective have been hamstrung. Therefore, using a Research Domain Criteria (RDoC) approach to examine irritability in adults, which spans many constructs and domains, may have a better chance of yielding underlying mechanisms that can then be mapped onto various diagnostic categories. Recently, a model has been proposed for irritability in children and adolescents that uses the RDoC framework; however, this model, which accounts for chronic, persistent irritability, may not necessarily transpose to adults. Therefore, use of the RDoC framework to examine irritability in adults is urgently needed, as it may shed light on this currently amorphous phenomenon and the many disorders within which it operates.

SUBMITTER: Bell E

PROVIDER: S-EPMC8058909 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Irritability through Research Domain Criteria: an opportunity for transdiagnostic conceptualisation.

Bell Erica E Bryant Richard A RA Boyce Philip P Porter Richard J RJ Malhi Gin S GS

BJPsych open 20210119 1

Irritability is a transdiagnostic phenomenon that, despite its ubiquity and significant impact, is poorly conceptualised, defined and measured. As it lacks specificity, efforts to examine irritability in adults by using a diagnostic category perspective have been hamstrung. Therefore, using a Research Domain Criteria (RDoC) approach to examine irritability in adults, which spans many constructs and domains, may have a better chance of yielding underlying mechanisms that can then be mapped onto v ...[more]

PMID: 33461648

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Project description:ImportanceOver the past decade, the leadership of the National Institute of Mental Health (NIMH) has emphasized the importance of a transdiagnostic approach to psychiatric investigation using Research Domain Criteria (RDoC) mapping more closely to neurobiology.ObjectiveTo investigate whether research support from the NIMH for individual RDoC domains and for transdiagnostic investigation has changed over time and has had differential impact in terms of publication, citations, or patent filings.Design, setting, and participantsIn this longitudinal cohort study, all R01, R21, and R03 studies funded by the NIMH between January 2003 and December 2023 were identified via the National Institutes of Health RePORTER database. Their abstracts were characterized in terms of RDoC domains (negative valence, positive valence, cognition, social, arousal, and sensorimotor) using a large language model.Main outcomes and measuresPrimary outcomes were publications, citation impact estimated at 5 years from the index year of funding, and patents, examined using regression models adjusted for other grant characteristics.ResultsAmong 8897 R01, R03, and R21 projects, reflecting $17.7 billion of investment, abstracts of 3141 (35.3%) reflected negative valence; 1344 (15.1%), positive valence; 2781 (31.3%), cognition; 1607 (18.1%), social; 343 (3.9%), arousal; and 571 (6.4%), sensorimotor domains. A total of 1793 (20.2%) incorporated a transdiagnostic perspective. Positive and social domains were associated with fewer publications (difference, -1.13 [95% CI, -2.11 to -0.15] and -2.23 [95% CI, -3.15 to -1.30], respectively) and lesser citation impact (difference, -0.47 [95% CI, -0.75 to -0.18] and -1.19 [95% CI, -1.46 to -0.91], respectively) at 5 years. Social (adjusted odds ratio [AOR], 0.11; 95% CI, 0.04-0.23) and cognitive (AOR, 0.66; 95% CI, 0.48-0.89) domains and transdiagnostic proposals (AOR, 0.37; 95% CI, 0.21-0.60) were associated with lower likelihood of patent filing.Conclusions and relevanceIn this study of NIMH funding, grants reflecting different RDoC domains differed substantially in their scientific impact in terms of publications, citations, and patent generation. The findings suggest that large language models represent a promising approach to characterizing research proposals at scale, which may be useful in guiding resource allocation to maximize scientific return on investment.

Dataset Information

Irritability through Research Domain Criteria: an opportunity for transdiagnostic conceptualisation.

Publications

Irritability through Research Domain Criteria: an opportunity for transdiagnostic conceptualisation.

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