Trained immunity induced by in vivo peptide-based STAT6 inhibition prevents ragweed allergy in mice.

ABSTRACT:

Background

Trained immunity is the ability of the innate immune system to form immune memory responses to provide support the formation of appropriate adaptive responses. Allergic airways disease (AAD) is a maladapted immune response to allergens, initiated and maintained by the type 2 (T2) inflammatory pathway. It is predicated by the elaboration of cytokines IL-4 and IL-13 and follows activation of the STAT6 transcription factor.

Objective

To investigate the role of trained immunity in mucosal immune responses following neonatal vaccination with the STAT6 inhibitory peptide (STAT6-IP), in preventing the development of ragweed-induced AAD.

Methods

We demonstrate that transfer of CD4⁺ T cells or dendritic cells (DC) from STAT6-IP vaccinated wild-type BALB/c

SUBMITTER: Michael H 

PROVIDER: S-EPMC8059037 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature