Impact of structural biologists and the Protein Data Bank on small-molecule drug discovery and development.

ABSTRACT: The Protein Data Bank (PDB) is an international core data resource central to fundamental biology, biomedicine, bioenergy, and biotechnology/bioengineering. Now celebrating its 50th anniversary, the PDB houses >175,000 experimentally determined atomic structures of proteins, nucleic acids, and their complexes with one another and small molecules and drugs. The importance of three-dimensional (3D) biostructure information for research and education obtains from the intimate link between molecular form and function evident throughout biology. Among the most prolific consumers of PDB data are biomedical researchers, who rely on the open access resource as the authoritative source of well-validated, expertly curated biostructures. This review recounts how the PDB grew from just seven protein s

SUBMITTER: Burley SK 

PROVIDER: S-EPMC8059052 | biostudies-literature | 2021 Jan-Jun

REPOSITORIES: biostudies-literature