A tunable population timer in multicellular consortia.

ABSTRACT: Processing time-dependent information requires cells to quantify the duration of past regulatory events and program the time span of future signals. At the single-cell level, timer mechanisms can be implemented with genetic circuits. However, such systems are difficult to implement in single cells due to saturation in molecular components and stochasticity in the limited intracellular space. In contrast, multicellular implementations outsource some of the components of information-processing circuits to the extracellular space, potentially escaping these constraints. Here, we develop a theoretical framework, based on trilinear coordinate representation, to study the collective behavior of populations composed of three cell types under stationary conditions. This framework reveals that dist

SUBMITTER: Toscano-Ochoa C 

PROVIDER: S-EPMC8059065 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature