Treatment of NAFLD with intermittent calorie restriction or low-carb high-fat diet - a randomised controlled trial.

ABSTRACT:

Background & aims

The first-line treatment for non-alcoholic fatty liver disease (NAFLD) is weight reduction. Several diets have been proposed, with various effects specifically on liver steatosis. This trial compared the effects of intermittent calorie restriction (the 5:2 diet) and a low-carb high-fat diet (LCHF) on reduction of hepatic steatosis.

Methods

We conducted an open-label randomised controlled trial that included 74 patients with NAFLD randomised in a 1:1:1 ratio to 12 weeks' treatment with either a LCHF or 5:2 diet, or general lifestyle advice from a hepatologist (standard of care; SoC). The primary outcome was reduction of hepatic steatosis as measured by magnetic resonance spectroscopy. Secondary outcomes included transient elastography, insulin resistance, bl

SUBMITTER: Holmer M 

PROVIDER: S-EPMC8059083 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature