Weight-loss-independent benefits of exercise on liver steatosis and stiffness in Japanese men with NAFLD.

ABSTRACT:

Background & aims

A weight-loss-independent beneficial effect of exercise on non-alcoholic fatty liver disease (NAFLD) management has been reported, but the underlying mechanism is unknown. To help determine this mechanism, the effects of exercise on individual tissues (liver, adipose tissue, and skeletal muscle) were retrospectively studied.

Methods

Data from Japanese obese men with NAFLD in a 3-month exercise regimen were analysed and compared with those in a 3-month dietary restriction program designed to achieve weight loss. The underlying mechanism was studied in a smaller subcohort.

Results

Independent of the effect of weight loss, the exercise regimen reduced liver steatosis by 9.5% and liver stiffness by 6.8% per 1% weight loss, and resulted in a 16.4% reducti

SUBMITTER: Oh S 

PROVIDER: S-EPMC8059085 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature