Allicin attenuates myocardial apoptosis, inflammation and mitochondrial injury during hypoxia-reoxygenation: an in vitro study.

ABSTRACT:

Background

Myocardial ischemia-reperfusion (IR) injury is a damage due to an initial reduction in blood flow to the heart, preventing it from receiving enough oxygen, and subsequent restoration of blood flow through the opening of an occluded coronary artery producing paradoxical harmful effects. The finding of new therapies to prevent IR is of utmost importance. Allicin is a compound isolated from garlic having the ability to prevent and cure different diseases, and a protective effect on the myocardium was also demonstrated. Therefore, the aim of this study was to evaluate the in vitro protective effect of Allicin against myocardial IR injury on cardiomyocytes.

Methods

We established an in vitro hypoxia-reoxygenation (HR) model of primary porcine cardiomyocytes to simulate

SUBMITTER: Deng X 

PROVIDER: S-EPMC8059159 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature