White matter microstructure associations with episodic memory in adults with Down syndrome: a tract-based spatial statistics study.

ABSTRACT:

Background

Nearly all persons with Down syndrome will show pathology of Alzheimer's disease in their 40s. There is a critical need for studies to identify early biomarkers of these various pathological changes of Alzheimer's disease in the Down syndrome population and understand the relationship of these biomarkers to cognitive symptoms in order to inform clinical trials. Although Alzheimer's disease is often considered a disease of gray matter, white matter degeneration has been documented during the preclinical stage of Alzheimer's disease. The current study examined the association between diffusion tensor imaging (DTI) measures of white matter microstructure and episodic memory performance in 52 adults with Down syndrome.

Methods

Seventy (N = 70) participants (M = 40.13,

SUBMITTER: Bazydlo A 

PROVIDER: S-EPMC8059162 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature