SNRPD1 confers diagnostic and therapeutic values on breast cancers through cell cycle regulation.

ABSTRACT:

Background

SNRPD1 is a spliceosome-associated protein and has previously been implicated with important roles in cancer development.

Methods

Through analyzing the differential expression patterns and clinical association of splicing associated genes among tumor and tumor adjacent samples across different tumors and among different breast cancer subtypes, we identify the tumor promotive role of SNRPD1 using multiple publicly available datasets. Through pathway, gene ontology enrichment analysis and network construction, we linked the onco-therapeutic role of SNRPD1 with cell cycle. Via a series of experimental studies including knockdown assay, qPCR, western blotting, cell cycle, drug response assay, we confirmed the higher expression of SNPRD1 at both gene and protein expres

SUBMITTER: Dai X 

PROVIDER: S-EPMC8059192 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature