General quantitative relations linking cell growth and the cell cycle in Escherichia coli.

ABSTRACT: Growth laws emerging from studies of cell populations provide essential constraints on the global mechanisms that coordinate cell growth^1-3. The foundation of bacterial cell cycle studies relies on two interconnected dogmas that were proposed more than 50 years ago-the Schaechter-Maaloe-Kjeldgaard growth law that relates cell mass to growth rate¹ and Donachie's hypothesis of a growth-rate-independent initiation mass⁴. These dogmas spurred many efforts to understand their molecular bases and physiological consequences^5-14. Although they are generally accepted in the fast-growth regime, that is, for doubling times below 1 h, extension of these dogmas to the slow-growth regime has not been consistently achieved. Here, through a quantitative physiolo

SUBMITTER: Zheng H 

PROVIDER: S-EPMC8059327 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature