Mitochondrial Homeostasis in AML and Gasping for Response in Resistance to BCL2 Blockade.
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ABSTRACT:
SUBMITTER: Savona MR
PROVIDER: S-EPMC8059329 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Mitochondrial Homeostasis in AML and Gasping for Response in Resistance to BCL2 Blockade.
Savona Michael R MR Rathmell Jeffrey C JC
Cancer discovery 20190701 7
Understanding resistance to BCL2 inhibition is a critical scientific and clinical challenge. In this issue of <i>Cancer Discovery</i>, two laboratories use unbiased approaches of large loss-of-function CRISPR/Cas 9 screens to discover targetable liabilities in cell signaling and metabolism to acute myeloid leukemia resistant to BCL2 inhibition.<i>See related article by Chen et al., p. 890</i>.<i>See related article by Nechiporuk et al., p. 910</i>. ...[more]
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