Clinical evaluation of Bladder CARE, a new epigenetic test for bladder cancer detection in urine samples.

ABSTRACT:

Background

Bladder cancer (BC) is the 5th most common cancer in the USA. Non-muscle invasive bladder cancer represents about 70% of all cases and has generally a favorable outcome. However, recurrence rates as high as 60 to 70% and progression rates of 10 to 20% necessitate intensive surveillance with cystoscopy. The invasiveness and high cost of cystoscopy poses significant burden on BC patients as well as on the healthcare system. In this study we test the feasibility of a simple, sensitive, and non-invasive detection of BC using Bladder CARE test in urine samples.

Results

Urine from 136 healthy and 77 BC subjects was collected using the at-home Bladder CARE Urine Collection Kit and analyzed with Bladder CARE test. The test measures the methylation level of three BC-specif

SUBMITTER: Piatti P 

PROVIDER: S-EPMC8059345 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature